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Cover Feature: Efficient Synthesis of Polysubstituted Furans through a Base‐Promoted Oxacyclization of ( Z )‐2‐En‐4‐yn‐1‐ols (Eur. J. Org. Chem. 27/2021)
Author(s) -
Hrizi Asma,
Thiery Emilie,
RomdhaniYounes Moufida,
Jacquemin Johan,
Thibonnet Jérôme
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100709
Subject(s) - cover (algebra) , chemistry , feature (linguistics) , base (topology) , variety (cybernetics) , combinatorial chemistry , computational chemistry , organic chemistry , stereochemistry , computer science , artificial intelligence , mathematics , engineering , mechanical engineering , mathematical analysis , philosophy , linguistics
The Cover Feature shows the experimental and theoretical approach to the synthesis of polysubstituted furans, prevalent structural motifs in natural products, bioactive compounds or functional organic materials. A methodological study has shown that potassium tert ‐butoxide promotes the oxacyclization of Z ‐enynols leading to a variety of di‐, tri‐, and tetra‐substituted furans. At the same time, the analysis of natural populations by DFT calculations made it possible to rationalize the feasibility of this reaction. We would like to thank Mr Martin Gilardi for the creation of this drawing. More information can be found in the Full Paper by J. Thibonnet et al.