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A Mild Glycosylation Protocol with Glycosyl 1‐Methylimidazole‐2‐carboxylates as Donors
Author(s) -
Chen Jianpeng,
Tang Yu,
Yu Biao
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100677
Subject(s) - chemistry , glycosyl , glycosylation , glycosyl donor , combinatorial chemistry , chelation , metal , stereochemistry , organic chemistry , medicinal chemistry , biochemistry
A mild glycosylation protocol is developed by using glycosyl 1‐methylimidazole‐2‐carboxylates. Such a glycosylation can be promoted by a series of metal triflates and triflimides, especially Cu(OTf) 2 . The reaction is initiated by activation of the glycosyl ester donor via coordination with the metal cation assisted by the adjacent 1‐methylimidazole chelating group.