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Xanthates as Thiol Surrogates for Nucleophilic Substitution with Aryl Halides
Author(s) -
Sokolov Anatolii I.,
Mikhaylov Andrey A.,
Baleeva Nadezhda S.,
Baranov Mikhail S.
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100647
Subject(s) - chemistry , xanthate , aryl , halide , thiol , alkyl , methanol , nucleophilic substitution , nucleophile , organic chemistry , combinatorial chemistry , catalysis
We herein report an unprecedented xanthate‐based protocol for the preparation of aryl‐alkyl thioethers. Heating xanthates with aryl halides and namely cesium carbonate in methanol provides the target thioethers in generally good yields within short reaction times. This method allows one to avoid contact with odorous thiols and also to introduce substituents of which the corresponding thiols are virtually unavailable or inconvenient in use.