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Synthesis of N‐Aryl‐ and N‐Alkenylhydrazides through C(sp 2 )−N Bond Construction
Author(s) -
Lei Jian,
Xie Wenqian,
Li Jing,
Wu Ya,
Xie Xiaolan
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100631
Subject(s) - chemistry , regioselectivity , moiety , hydrazide , aryl , molecule , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , alkyl
N‐Aryl‐ and N‐alkenylhydrazides, which include a C(sp 2 )‐N−N motif, have attracted considerable attention not only in biologically active molecules but also because of their extensive technical applications in organic synthesis. C(sp 2 )−N bond construction protocols using an N‐acylhydrazine or azocarboxylic ester as the hydrazide source provide a powerful route to these compounds. These protocols exhibit different selectivity manner for the C(sp 2 ) moiety and the regioselectivity issue of the N−N bond. This Minireview documents the available methods that have been developed based on different starting materials. The features and drawbacks of each subdivisional methodology are demonstrated.