Premium
One‐step Conversion of Amides and Esters to Acid Chlorides with PCl 3
Author(s) -
Li Fangshao,
Wu Xiaofang,
Guo Fengzhe,
Tang ZiLong,
Xiao Jing
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100630
Subject(s) - chemistry , organic chemistry , scope (computer science) , substrate (aquarium) , phosphorus trichloride , amide , iodine , carboxylic acid , combinatorial chemistry , oceanography , computer science , programming language , geology
A general and efficient iodine‐promoted chlorination of amides and esters with phosphorus trichloride is described. For the first time. Various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one‐step. The substrate scope of methyl esters including aromatic and aliphatic esters was also explored under this system. This method is simple, scalable and wide in scope, which provides an approach to preparation of these acid chlorides.