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Rh(III)‐Catalyzed [4+2] Cyclization of 2‐Aryl‐1 H ‐benzo[ d ]imidazoles with Maleimides via C‐H Activation
Author(s) -
Deng Chen,
Li Changchang,
Yao Jinzhong,
Jin Quanli,
Miao Maozhong,
Zhou Hongwei
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100612
Subject(s) - chemistry , catalysis , rhodium , aryl , substrate (aquarium) , formal synthesis , medicinal chemistry , stereochemistry , scope (computer science) , combinatorial chemistry , organic chemistry , alkyl , oceanography , geology , computer science , programming language
Abstract A rhodium‐catalyzed formal [4+2]‐cyclization of 2‐aryl‐1 H ‐benzo[ d ]imidazoles with maleimides through C−H bond activation process is described here. Such an approach enables selectively construct a series of functionalized cis ‐dihydro‐benzimidazo[2,1‐ a ]isoquinolines. The reaction features a broad substrate scope with respect to both coupling components, and the desired products were obtained with up to 85 % yields.