Rh(III)‐Catalyzed [4+2] Cyclization of 2‐Aryl‐1 H ‐benzo[ d ]imidazoles with Maleimides via C‐H Activation | Zendy

Deng Chen | Zendy; Li Changchang | Zendy; Yao Jinzhong | Zendy; Jin Quanli | Zendy; Miao Maozhong | Zendy; Zhou Hongwei | Zendy

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Rh(III)‐Catalyzed [4+2] Cyclization of 2‐Aryl‐1 H ‐benzo[ d ]imidazoles with Maleimides via C‐H Activation

Author(s) -

Deng Chen,

Li Changchang,

Yao Jinzhong,

Jin Quanli,

Miao Maozhong,

Zhou Hongwei

Publication year - 2021

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202100612

Subject(s) - chemistry , catalysis , rhodium , aryl , substrate (aquarium) , formal synthesis , medicinal chemistry , stereochemistry , scope (computer science) , combinatorial chemistry , organic chemistry , alkyl , oceanography , geology , computer science , programming language

A rhodium‐catalyzed formal [4+2]‐cyclization of 2‐aryl‐1 H ‐benzo[ d ]imidazoles with maleimides through C−H bond activation process is described here. Such an approach enables selectively construct a series of functionalized cis ‐dihydro‐benzimidazo[2,1‐ a ]isoquinolines. The reaction features a broad substrate scope with respect to both coupling components, and the desired products were obtained with up to 85 % yields.

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