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Efficient Preparation of Methyl 2‐Oxo‐3‐aryl (heteroaryl)‐2 H ‐pyran‐5‐carboxylate via Pd‐Catalyzed Negishi Coupling
Author(s) -
Xavier Tania,
Pichon Christophe,
Presset Marc,
Le Gall Erwan,
Condon Sylvie
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100608
Subject(s) - chemistry , negishi coupling , carboxylate , aryl , catalysis , pyran , palladium , reagent , medicinal chemistry , organic chemistry , alkyl
Methyl 3‐bromocoumalate, readily obtained from methyl 2‐pyrone‐5‐carboxylate (methyl coumalate), is easily substituted by cross‐coupling reactions with arylzinc reagents under palladium catalysis, leading to methyl 2‐oxo‐3‐aryl (heteroaryl)‐2H‐pyran‐5‐carboxylates.