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Cover Feature: The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions. (Eur. J. Org. Chem. 20/2021)
Author(s) -
Rosalba Thaissa Pasquali F.,
Kas Samia Sayegh A.,
Sampaio Ana Beatriz S.,
Salvador Carlos Eduardo M.,
Andrade Carlos Kleber Z.
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100579
Subject(s) - hexamethylenetetramine , chemistry , formaldehyde , cover (algebra) , ammonia , metamorphosis , feature (linguistics) , carboxylic acid , combinatorial chemistry , organic chemistry , ecology , mechanical engineering , linguistics , philosophy , larva , engineering , biology
The Cover Feature shows a combination that could be called the ugly duckling of the Ugi 4‐component reactions, which involves the concomitant use of the ammonia/formaldehyde pair. There was not a single methodology so far to successfully achieve this goal. The metamorphosis could finally happen with the intermediacy of hexamethylenetetramine (HMTA), which allows the in situ generation of both ammonia and formaldehyde for the Ugi reactions with carboxylic acids and isocyanides, yielding a variety of acylaminoacetamide derivatives in good to excellent yields. More information can be found in the Full Paper by C. K. Z. Andrade et al.