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Front Cover: Copper‐Free One‐Pot Sonogashira‐Type Coupling for the Efficient Preparation of Symmetric Diarylalkyne Ligands for Metal‐Organic Cages (Eur. J. Org. Chem. 19/2021)
Author(s) -
Lehr Marc,
Paschelke Tobias,
Bendt Victoria,
Petersen André,
Pietsch Lorenz,
Harders Patrick,
McConnell Anna J.
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100533
Subject(s) - sonogashira coupling , chemistry , front cover , halide , cover (algebra) , aryl , ligand (biochemistry) , combinatorial chemistry , copper , organic synthesis , metal , coupling (piping) , palladium , stereochemistry , polymer chemistry , organic chemistry , catalysis , receptor , mechanical engineering , alkyl , biochemistry , engineering
The Front Cover shows a public transportation map representing the synthetic trip from an aryl halide to a heterocyclic diarylalkyne ligand. The “multi‐stop” route or conventional step‐wise synthesis involves long reaction times and “stops” for the isolation of intermediates. In contrast, the reported “non‐stop” route via a one‐pot copper‐free Sonogashira‐type coupling is faster and avoids the formation of Glaser products or “accidents”. Application of the ligands in the self‐assembly of metal‐organic cages is represented by the airport. The map background represents the Kiel fjord area. More information can be found in the Full Paper by A. J. McConnell et al.