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Visible Light‐Induced Metal‐Free and Oxidant‐Free Radical Cyclization of (2‐Isocyanoaryl)(methyl)sulfanes with Ethers
Author(s) -
Xie XiaoYu,
Li Yang,
Xia YunTao,
Luo Kai,
Wu Lei
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100501
Subject(s) - chemistry , radical , ether , photochemistry , cascade , photocatalysis , organic chemistry , free radical reaction , metal , radical cyclization , blue light , combinatorial chemistry , catalysis , physics , chromatography , optics
A novel cascade cyclization of (2‐isocyanoaryl) (methyl)sulfanes and ethers is developed. With 4CzIPN as a photocatalyst and the irradiation of blue LED light, ether radicals are efficiently generated without adding any oxidant, endowing the strategy with features of oxidant‐free, metal‐free, mild reaction conditions, and operational simplicity. This strategy provides efficient approach to access various ether‐containing benzothiazoles in acceptable to good yields.