Premium
Direct C3 Carbamoylation of 2 H ‐Indazoles
Author(s) -
Bhat Vighneshwar Shridhar,
Lee Anna
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100461
Subject(s) - chemistry , ammonium persulfate , persulfate , radical , catalysis , combinatorial chemistry , reaction conditions , organic chemistry , polymer , polymerization
We developed a novel method for direct C3 carbamoylation of 2 H ‐indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2 H ‐indazoles to afford the desired products. The reaction proceeds under metal‐ and catalyst‐free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2 H ‐indazoles, which are important scaffolds in organic synthesis.