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One‐Pot Synthesis of α‐Amino Nitrile Units through Alkylative Strecker Cyanation from Formamides
Author(s) -
Yu Bao,
Bodinier Florent,
SaagueTenefo Maximiliene,
Gerardo Patrice,
Ardisson Janick,
Lannou MarieIsabelle,
Sorin Geoffroy
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100418
Subject(s) - strecker amino acid synthesis , formamides , cyanation , chemistry , nitrile , aryl , organic chemistry , alkyl , reagent , cyanide , trimethylsilyl cyanide , yield (engineering) , combinatorial chemistry , formamide , enantioselective synthesis , materials science , metallurgy , catalysis
In this work, we describe the one‐pot synthesis of α‐amino nitrile units by the concomitant addition of alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in scope and the conditions are mild, inexpensive, and easy to set‐up, providing numerous α‐amino nitriles in good yields (34 examples, 41–94 % yield).