Premium
The Development of Organocatalytic Asymmetric Reduction of Carbonyls and Imines Using Silicon Hydrides
Author(s) -
Chen Wenchao,
Tan ChoonHong,
Wang Hong,
Ye Xinyi
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100394
Subject(s) - enantioselective synthesis , chemistry , organocatalysis , hydride , silicon , reduction (mathematics) , catalysis , combinatorial chemistry , asymmetric hydrogenation , organic chemistry , nanotechnology , materials science , hydrogen , geometry , mathematics
Abstract The asymmetric reduction of prochiral ketones and ketimines represents one of the most important and practical chemical transformations toward the synthesis of valuable chiral alcohols and amines. Among the existing strategies, organocatalyzed asymmetric reduction of carbonyls and imines using silicon hydrides is attractive due to low‐cost, chemical stability, and easy handling in experiments. In this review, we wish to highlight the recent progress made in the past fifteen years in this field. Four catalytic systems of different activation modes are presented and discussed in detail. We aim to help shed light on common features that enable highly enantioselective silicon hydride reductions through organocatalysis and provide the design principles for the development of more effective catalytic systems.