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Exploiting the Versatility of Palladium Catalysis: A Modern Toolbox for Cascade Reactions
Author(s) -
Mondal Sourav,
Ballav Tamal,
Biswas Krishna,
Ghosh Suman,
Ganesh Venkataraman
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100312
Subject(s) - cascade , chemistry , palladium , organic synthesis , combinatorial chemistry , cascade reaction , organic reaction , nanotechnology , catalysis , organic chemistry , materials science , chromatography
Palladium‐catalyzed cascade cyclization received much attention in organic synthesis due to its efficiency and rapid transformation of simple starting materials into complex molecular skeletons. Celebrating the 10 th year of the prestigious Nobel prize for palladium chemistry, we witness it still proceeds strong over other transition metals for its versatility. Cascade reactions in contemporary organic synthesis reduced cost and time through careful design. It has emerged as the first choice, a powerful tool for multiple bond formations in one step with a wide range of functional group tolerance due to the deep understanding of various pathways. A variety of compounds with biological relevance with complex molecular scaffolds have been achieved using these cascade coupling reactions. This review outlines Pd‐catalyzed cascade reactions from the post‐Nobel era. Nevertheless, more discoveries and endless possibilities for new transformations are underway.