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The Cross‐Dehydrogenative Coupling Reaction of β‐Ketoesters with Quinoxalin‐2(1 H )‐ones
Author(s) -
Zhang HongYu,
Yang Zibing,
Zhang Huizhen,
Han YaPing,
Zhao Jiquan,
Zhang Yuecheng
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100310
Subject(s) - chemistry , salt (chemistry) , functional group , catalysis , ionic bonding , combinatorial chemistry , coupling reaction , reaction conditions , transformation (genetics) , medicinal chemistry , coupling (piping) , stereochemistry , organic chemistry , ion , biochemistry , mechanical engineering , polymer , engineering , gene
The cross‐dehydrogenative coupling (CDC) reaction of β‐ketoesters with quinoxalin‐2(1 H )‐one derivatives has been successfully performed by using a readily available Cu salt as the catalyst in moderate to excellent yields under mild conditions. Owing to the characteristic of handy operation and good functional group tolerance, this protocol affords a convenient access to α‐quinoxalinone‐substituted β‐ketoesters. Preliminary mechanistic investigations show this transformation possibly underwent an unusual ionic pathway.