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Metal‐Free Direct Oxidative C−N Bond Coupling of Quinoxalin‐2(1 H )‐ones with Azoles under Mild Conditions
Author(s) -
Guo Jingwen,
Zhang Lina,
Du Xinyue,
Zhang Liting,
Cai Yuepiao,
Xia Qinqin
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100269
Subject(s) - chemistry , amination , yield (engineering) , combinatorial chemistry , oxidative phosphorylation , oxidative coupling of methane , medicinal chemistry , radical , stereochemistry , coupling reaction , organic chemistry , catalysis , biochemistry , materials science , metallurgy
Direct C3−H amination of quinoxalin‐2(1 H )‐ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram‐scale reaction.