Metal‐Free Direct Oxidative C−N Bond Coupling of Quinoxalin‐2(1 H )‐ones with Azoles under Mild Conditions | Zendy

Guo Jingwen | Zendy; Zhang Lina | Zendy; Du Xinyue | Zendy; Zhang Liting | Zendy; Cai Yuepiao | Zendy; Xia Qinqin | Zendy

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Metal‐Free Direct Oxidative C−N Bond Coupling of Quinoxalin‐2(1 H )‐ones with Azoles under Mild Conditions

Author(s) -

Guo Jingwen,

Zhang Lina,

Du Xinyue,

Zhang Liting,

Cai Yuepiao,

Xia Qinqin

Publication year - 2021

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202100269

Subject(s) - chemistry , amination , yield (engineering) , combinatorial chemistry , oxidative phosphorylation , oxidative coupling of methane , medicinal chemistry , radical , stereochemistry , coupling reaction , organic chemistry , catalysis , biochemistry , materials science , metallurgy

Direct C3−H amination of quinoxalin‐2(1 H )‐ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram‐scale reaction.

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