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Streamlined One‐Pot Synthesis of Nitro Fatty Acids
Author(s) -
Hassan Mohamed,
Krieg SaraCathrin,
Ndefo Nde Cedric,
Roos Jessica,
Maier Thorsten J.,
El Rady Eman A.,
Raslan Mohamed A.,
Sadek Kamal U.,
Manolikakes Georg
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100247
Subject(s) - chemistry , nitro , stereoselectivity , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , alkyl
A novel method for the synthesis of nitro fatty acids (NFAs), an intriguing class of endogenously occurring lipid mediators, is reported. This one‐pot procedure enables the controlled and stereoselective construction of nitro fatty acids from a simple set of common building blocks in a highly facile manner. Thereby, this methodology offers a streamlined, highly modular access to naturally occurring nitro fatty acids as well as non‐natural NFA derivatives.