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Fishing in the Toolbox of Cyclic Turn Mimics: a Literature Overview of the Last Decade
Author(s) -
Bucci Raffaella,
Foschi Francesca,
Loro Camilla,
Erba Emanuela,
Gelmi Maria Luisa,
Pellegrino Sara
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100244
Subject(s) - peptidomimetic , chemistry , cyclic peptide , toolbox , turn (biochemistry) , nanotechnology , combinatorial chemistry , peptide , biochemistry , engineering , mechanical engineering , materials science
The main goal in developing peptidomimetics is the stabilization of the bioactive conformation of peptides. Among all the secondary structures, turns are of paramount importance. This review highlights the recent advances in the design and synthesis of cyclic turn mimics. Both amino acids, carbo‐ and hetero‐cyclic scaffolds have been considered, focusing on their use in the preparation of peptidomimetics and on their ability to induce γ‐, β‐, and α‐turns.