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Copper‐Catalyzed Direct Oxidative α‐Alkoxylation of 4‐Isochromanones
Author(s) -
Wu Xiang,
Song ShuangGui,
Zhang Xin,
Fu YanMing,
Zhu ChengFeng,
Li YouGui
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100243
Subject(s) - chemistry , regioselectivity , catalysis , oxidative phosphorylation , copper , substrate (aquarium) , scope (computer science) , combinatorial chemistry , organic chemistry , biochemistry , oceanography , computer science , programming language , geology
The direct oxidative α‐alkoxylation of carbonyl compounds is very important, highly desirable but relatively rare. A general and convenient approach has been developed to prepare 3‐oxy‐4‐isochromanones by copper‐catalyzed α‐C(sp 3 )−H alkoxylation of 4‐isochromanones with alcohols. The key features are easily available starting materials, mild reaction conditions, broad substrate scope, and excellent regioselectivity.