One‐Pot Oxidation of Secondary Alcohols to  α ‐Hydroxy Ketones: Application to Synthesis of Oxoaplysinopsin D, E, F, & G | Zendy

Kulkarni Akshay S. | Zendy; Ramesh Eagala | Zendy; Srinivasa Reddy D. | Zendy

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One‐Pot Oxidation of Secondary Alcohols to α ‐Hydroxy Ketones: Application to Synthesis of Oxoaplysinopsin D, E, F, & G

Author(s) -

Kulkarni Akshay S.,

Ramesh Eagala,

Srinivasa Reddy D.

Publication year - 2021

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202100184

Subject(s) - chemistry , pyridinium , substrate (aquarium) , alcohol oxidation , organic chemistry , ketone , hydantoin , medicinal chemistry , combinatorial chemistry , alcohol , oceanography , geology

A simple one‐pot transformation of secondary alcohols to α ‐hydroxy ketones using pyridinium dichromate (PDC) in DMF has been developed and substrate scope tested with 25 compounds of hydantoin derivatives. Using this method, we have devised a common dihydroxy intermediate and synthesized four natural products oxoaplysinopsins D, E, F, and G for the first time.

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