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Copper‐Catalyzed Difluoroalkylation‐Thiolation of Alkenes Promoted by Na 2 S 2 O 5
Author(s) -
Gao Bao,
Ni Yingjie,
Liu Xiaojun,
Jiang Tao,
Yan Qian,
Yang Ruiting,
Zhang Xiuli
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100091
Subject(s) - chemistry , catalysis , substrate (aquarium) , selectivity , combinatorial chemistry , copper , functional group , reaction conditions , scope (computer science) , organic chemistry , oceanography , polymer , computer science , programming language , geology
A novel and convenient protocol for the difluoroalkylation‐thiolation of alkenes catalyzed by Cu/Na 2 S 2 O 5 system has been developed. This reaction was carried out using readily available starting materials under mild conditions, wherein the C−C and C−S bonds simultaneously were constructed smoothly. The reaction features broad substrate scope of alkenes and disulfides, good functional group tolerance, and good to excellent yields with high selectivity.