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Diaryliodonium Salts in Transition‐Metal‐Catalyzed Chelation‐Induced C(sp 2 /sp 3 )−H Arylations
Author(s) -
Joshi Asha,
De Saroj Ranjan
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100066
Subject(s) - chemistry , chelation , transition metal , aryl , catalysis , metallacycle , salt (chemistry) , oxidative addition , context (archaeology) , stereochemistry , medicinal chemistry , combinatorial chemistry , metal , organic chemistry , x ray crystallography , paleontology , alkyl , physics , diffraction , optics , biology
Transition‐metal‐catalyzed Cross‐coupling via directing group assisted C−H bond activation has become an expedient tool in current synthesis to achieve diverse molecular complexity. In this context, chelation‐assisted arylations of C(sp 2 /sp 3 )−H bonds have been extensively investigated as aryl/biaryl derivatives are an important contributor in the area of the industry, farming, medicinal and material science. The diaryliodonium salt has been broadly utilized in C(sp 2 /sp 3 )−H bond arylation where the reaction proceeds via oxidative addition of aryliodonium salt to chelation induced metallacycle. The proximal/remote C(sp 2 /sp 3 )−H bonds in coordination with transition metals are arylated by a range of directing groups in good to excellent yields. In this mini‐review, we have outlined the up to date developments on transition‐metal‐catalyzed chelation assisted C(sp 2 /sp 3 )−H bond arylation utilizing diaryliodonium salts as the coupling partner.