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Front Cover: Chiral Molecular Cages Based on Cyclotriveratrylene and Sucrose Units Connected with p ‐Phenylene Linkers (Eur. J. Org. Chem. 6/2021)
Author(s) -
Szyszka Łukasz,
Cmoch Piotr,
Górecki Marcin,
Ceborska Magdalena,
Potopnyk Mykhaylo A.,
Jarosz Sławomir
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100061
Subject(s) - chemistry , enantiopure drug , front cover , phenylene , nuclear magnetic resonance spectroscopy , stereochemistry , crystallography , computational chemistry , cover (algebra) , organic chemistry , catalysis , polymer , enantioselective synthesis , mechanical engineering , engineering
The Front Cover shows four diastereoisomeric molecular cages based on cyclotriveratrylene (CTV) and sucrose units connected via p ‐phenylene linkers. The few steps reaction between CTV and sucrose derivatives leads to, very uncommon, enantiopure C1 symmetrical hemicryptophanes. Combination of chiral, naturally occurring sucrose scaffold with CTV unit ensures a unique shape of the cages. These chiral cages were successfully separated using preparative HPLC, and their absolute configuration was determined by advanced NMR techniques and ECD spectroscopy supported by DFT calculations. More information can be found in the Full Paper by Ł. Szyszka, S. Jarosz et al.