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Synthesis of Isatin‐Hydrazones from 3‐Diazo Oxindoles and Sulfoxonium Ylides under Catalyst‐ and Additive‐Free Conditions
Author(s) -
Tian Yu,
Zhang Zunting,
Wang Tao
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100060
Subject(s) - diazo , chemistry , electrophile , isatin , catalysis , nucleophile , organic chemistry , combinatorial chemistry
A facile synthesis of isatin‐hydrazones from 3‐diazo oxindoles and sulfoxonium ylides under catalyst‐ and additive‐free conditions is described. A plausible reaction pathway is proposed for the transformation, in which diazo compounds play as electrophiles to react with nucleophilic sulfoxonium ylides. The reaction mechanism is supported by the experimental evidence.