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Rh(III)‐Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with CF 3 ‐Containing α ‐Propargyl α ‐Amino Acid Derivatives
Author(s) -
Vorobyeva Daria V.,
Petropavlovskikh Dmitry A.,
Godovikov Ivan A.,
Nefedov Sergey E.,
Osipov Sergey N.
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100040
Subject(s) - chemistry , annulation , propargyl , pharmacophore , aryl , catalysis , amino acid , stereochemistry , medicinal chemistry , organic chemistry , alkyl , biochemistry
A series of new orthogonally protected α ‐CF 3 ‐substituted α ‐amino carboxylates, and α‐amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)‐catalyzed C−H activation/annulation of aryl hydroxamates with propargyl‐containing α ‐amino acid derivatives and their phosphorus analogues.