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A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues
Author(s) -
Chiurchiù Elena,
Sampaolesi Susanna,
Allegrini Pietro,
Ciceri Daniele,
Ballini Roberto,
Palmieri Alessandro
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001633
Subject(s) - cannabidiol , chemistry , limiting , cannabis sativa , tetrahydrocannabinol , cannabis , cannabinoid , nanotechnology , combinatorial chemistry , biochemistry , mechanical engineering , psychology , botany , receptor , psychiatry , engineering , biology , materials science
Cannabidiol is one of the main non‐psychoactive cannabinoids present in Cannabis sativa and, in the last decade, it is gaining great interest among the scientific community for its pharmaceutical, nutraceutical, and cosmetic applications. Herein, we report the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB). This approach permits to synthesize products in very good yields (55–59 %), limiting the formation of psychoactive and illegal cannabinoids such as tetrahydrocannabinol (THC).