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N‐Heterocyclic Carbene Catalyzed [3+2] Annulations of β‐Halocycloenals with Isatins and Mechanism Study
Author(s) -
Wang Gang,
Wu Jiang,
Cheng Hang,
Zhong Cheng,
He ZhaoLin
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001544
Subject(s) - chemistry , carbene , catalysis , isatin , mechanism (biology) , combinatorial chemistry , transformation (genetics) , reaction mechanism , dual role , dual (grammatical number) , stereochemistry , computational chemistry , organic chemistry , biochemistry , art , philosophy , literature , epistemology , gene
An NHC‐catalyzed [3+2] annulations of β‐halocycloenals with isatins upon a dual‐activation mode was developed for the synthesis of tetracyclic 3‐spirooxindoles. DFT calculations were performed for the mechanism study of this transformation.