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Iodine‐Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives
Author(s) -
Rong Xiaona,
Guo Jingwen,
Hu Zheqi,
Huang Lehao,
Gu Yugui,
Cai Yuepiao,
Liang Guang,
Xia Qinqin
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001510
Subject(s) - chemistry , sulfonyl , iodine , sulfone , organic chemistry , coupling reaction , combinatorial chemistry , catalysis , alkyl
An efficient iodine‐mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.
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