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Chemistry for the Identification of Therapeutic Targets: Recent Advances and Future Directions
Author(s) -
KhiarFernández Nora,
Macicior Jon,
MarcosRamiro Beatriz,
OrtegaGutiérrez Silvia
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001507
Subject(s) - identification (biology) , chemistry , chemical biology , drug discovery , biochemical engineering , nanotechnology , computational biology , management science , data science , computer science , engineering , biology , biochemistry , botany , materials science
The increasing availability of chemical probes for specific applications in chemical biology and medicinal chemistry is extensively facilitating our knowledge of biological systems. This understanding has fundamental implications in the development of new efficacious therapeutic strategies. Nowadays, successful drug discovery programs consider identification, engagement, and endogenous levels of the intended therapeutic target from the earliest preclinical stages. All these aspects are addressed with the use of chemical probes, compounds that rely on the use of a particular chemical reaction to give an answer to a specific biological question. In this review we will describe the underlying chemistry and the most recent advances experienced in the field together with their most important biomedical applications.