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Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines
Author(s) -
Chen Zhiwei,
Shi Guang,
Tang Wei,
Sun Jie,
Wang Wenxing
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001484
Subject(s) - chemistry , annulation , pyrrole , electrochemistry , combinatorial chemistry , intermolecular force , oxidative coupling of methane , oxidative phosphorylation , organic chemistry , molecule , catalysis , biochemistry , electrode
A conceptually novel method for the preparation of pyrrole is described by electrochemical‐oxidation‐induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate‐facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant‐free condition. This electrosynthetic approach providing an environmentally benign protocol for C−C bond cross‐coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.