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2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)‐Mediated Tandem Oxidative Annulation for Preparing 2,2‐Disubstituted 2,3‐Dihydroquinazolin‐4(1H)‐ones
Author(s) -
Cheng Dongping,
Yan Xianhang,
Pu Yueqi,
Shen Jing,
Xu Xiaoliang,
Yan Jizhong
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001479
Subject(s) - chemistry , annulation , tandem , oxidative phosphorylation , oxidative coupling of methane , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , materials science , composite material
An efficient tandem oxidative annulation for the synthesis of 2,2‐disubstituted 2,3‐dihydroquinazolin‐4(1H)‐ones via DDQ‐mediated dual cross‐dehydrogenative‐coupling (CDC) reactions is described. This transformation proceeds from easily available o ‐aminobenzamides and 1,3‐diarylpropenes under mild conditions, and the corresponding products are obtained in moderate to excellent yields.