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Visible Light‐Driven Efficient Synthesis of Amides from Alcohols using Cu−N−TiO 2 Heterogeneous Photocatalyst
Author(s) -
Singha Krishnadipti,
Ghosh Subhash Chandra,
Panda Asit Baran
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001466
Subject(s) - chemistry , catalysis , photocatalysis , visible spectrum , substrate (aquarium) , combinatorial chemistry , functional group , alcohol oxidation , organic chemistry , physics , oceanography , polymer , optoelectronics , geology
Amides were synthesized from alcohols and amines in high yields using an in situ generated active ester of N ‐hydroxyimide with our developed Cu−N−TiO 2 catalyst at room temperature using oxygen as a sole oxidant under visible light. The catalyst can be easily prepared, robust, and recycled four times without a considerable change in catalytic activity. This developed protocol applies to a wide substrate scope and has good functional group tolerance. The application of this amidation reaction has been successfully demonstrated for the synthesis of moclobemide, an antidepressant drug, and an analog of the itopride drug on a gram scale.