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Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism
Author(s) -
Ikeda Yuko,
Matsukawa Yuko,
Yonekura Kyohei,
Shirakawa Eiji
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001457
Subject(s) - chemistry , homolysis , radical , mechanism (biology) , radical cyclization , chain reaction , radical nucleophilic aromatic substitution , free radical reaction , medicinal chemistry , stereochemistry , photochemistry , organic chemistry , nucleophilic aromatic substitution , nucleophilic substitution , philosophy , epistemology
In the presence of a substoichiometric amount of a tert ‐butoxy radical precursor and a base, alkylamides were found to be heteroarylated at their α‐C−H bonds with sulfonylheteroarenes through homolytic aromatic substitution, where a radical chain is operative.