Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism | Zendy

Ikeda Yuko | Zendy; Matsukawa Yuko | Zendy; Yonekura Kyohei | Zendy; Shirakawa Eiji | Zendy

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Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism

Author(s) -

Ikeda Yuko,

Matsukawa Yuko,

Yonekura Kyohei,

Shirakawa Eiji

Publication year - 2021

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202001457

Subject(s) - chemistry , homolysis , radical , mechanism (biology) , radical cyclization , chain reaction , radical nucleophilic aromatic substitution , free radical reaction , medicinal chemistry , stereochemistry , photochemistry , organic chemistry , nucleophilic aromatic substitution , nucleophilic substitution , philosophy , epistemology

In the presence of a substoichiometric amount of a tert ‐butoxy radical precursor and a base, alkylamides were found to be heteroarylated at their α‐C−H bonds with sulfonylheteroarenes through homolytic aromatic substitution, where a radical chain is operative.

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