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Quinoline Ligands Improve the Classic Direct C−H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans
Author(s) -
Mackey Katrina,
Jones David J.,
Pardo Leticia M.,
McGlacken Gerard P.
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001416
Subject(s) - chemistry , quinoline , intramolecular force , combinatorial chemistry , ligand (biochemistry) , organic chemistry , receptor , biochemistry
The C−H functionalisation approach to the synthesis of dibenzofurans is hampered by a number of problems. Herein we describe the evolution of a cheap, bench stable quinoline ligand, which obviates most of the current limitations and allows for a high yielding synthesis of a range of valuable dibenzofurans. Dibenzofurans are important motifs in natural products and compounds with wide biological activity.