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KO t ‐Bu‐Catalyzed Chemo‐ and Regioselective Hydroamination of Allylic Sulfones with Indoles
Author(s) -
Kim Kundo,
Park Subin,
Lee Yunmi
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001394
Subject(s) - regioselectivity , chemistry , allylic rearrangement , hydroamination , indole test , catalysis , sulfonyl , combinatorial chemistry , sulfone , medicinal chemistry , organic chemistry , stereochemistry , alkyl
A highly chemo‐ and regioselective KO t ‐Bu‐catalyzed addition of substituted indoles to terminal or disubstituted allylic sulfones at the indole N ‐position is reported. The catalytic protocol allows for the efficient and mild synthesis of a broad range of new and versatile sulfonyl‐substituted indoles and azoles bearing various functional groups from readily available starting materials in good to excellent yields with complete regioselectivity.