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Diversified Syntheses of Tetrathia[7]helicenes by Metal‐Catalyzed Cross‐Coupling Reactions
Author(s) -
Pelliccioli Valentina,
Dova Davide,
Baldoli Clara,
Graiff Claudia,
Licandro Emanuela,
Cauteruccio Silvia
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001382
Subject(s) - chemistry , sonogashira coupling , cycloisomerization , annulation , palladium , regioselectivity , catalysis , combinatorial chemistry , halogenation , suzuki reaction , stereochemistry , medicinal chemistry , organic chemistry
Efficient and versatile synthetic routes to functionalized tetrathia[7]helicenes (7‐THs) are described. The key intermediates of these methodologies are 2‐bromo‐3,3′‐bibenzo[1,2‐ b :4,3‐ b ′]dithiophenes ( 1 ), synthesized through a palladium‐catalyzed homocoupling reaction between two benzo[1,2‐ b :4,3‐ b ′]dithiophene units followed by a regioselective α‐bromination. Direct palladium‐catalyzed annulation of bromides 1 with internal alkynes provides a set of 7,8‐disubstituted 7‐THs 2 in moderate to good yields (46‐80 %). Otherwise, 7‐monosubstituted 7‐THs 4 have been prepared through Sonogashira coupling of 1 with terminal alkynes, followed by platinum‐ or indium‐promoted cycloisomerization of alkynyl intermediates 6 . Finally, the versatility of bromides 1 has also been demonstrated by using them for the preparation of benzo (hetero) fused 7‐TH derivatives 7 via Suzuki coupling with (hetero)arylboronic acids and the photocyclization of the obtained intermediates 9 .