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Chitosan‐Silicon Phthalocyanine Conjugate as Effective Photo‐Functional Hydrogel for Tracking and Killing of Bacteria
Author(s) -
Strokov Konstantin,
Galstyan Anzhela
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001363
Subject(s) - chemistry , conjugate , conjugated system , chromophore , phthalocyanine , chitosan , antibacterial activity , combinatorial chemistry , fluorescence , drug delivery , photochemistry , derivative (finance) , silicon , self healing hydrogels , nanotechnology , polymer chemistry , organic chemistry , bacteria , polymer , materials science , genetics , mathematical analysis , mathematics , biology , physics , quantum mechanics , financial economics , economics
Hydrogels are attractive materials for many biomedical applications, including drug delivery and wound healing. A light‐triggered antibacterial activity can be conferred to the material with the introduction of appropriate photosensitizers (PS). In this study, we have synthesized water‐soluble silicon(IV)phthalocyanine derivative (SiPc) that contains four carboxylic groups on the periphery of the macrocycle. Obtained PS serves not only as an active chromophore but also as a cross‐linking gelator, enabling simple and easy synthesis of chitosan conjugate (SiPcCh). Although UV/Vis and fluorescence spectroscopic methods showed that both free and conjugated PS are non‐aggregated in water media, only SiPcCh possess remarkable antibacterial effect against Gram‐positive B. subtilis and Gram‐negative E. coli .