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Photochemical Synthesis of Benzimidazoles from Diamines and Aldehydes
Author(s) -
Skolia Elpida,
Apostolopoulou Mary K.,
Nikitas Nikolaos F.,
Kokotos Christoforos G.
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001357
Subject(s) - chemistry , photoinitiator , photochemistry , reaction mechanism , combinatorial chemistry , organic chemistry , catalysis , polymer , monomer
An efficient, green, cheap, and metal‐free photochemical protocol for the synthesis of benzimidazoles has been developed. 2,2‐Dimethoxy‐2‐phenylacetophenone was employed as the photoinitiator and CFL lamps were used as the light source, leading to the cyclization of substituted diamines with aldehydes. The corresponding benzimidazoles were obtained in good to high yields. Mechanistic studies were conducted, in order to determine a plausible mechanism for the reaction.