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Metal‐Free Hydrophosphoryloxylation of Ynamides: Rapid Access to Enol Phosphates
Author(s) -
An Dalie,
Zhang Weinan,
Pan Bin,
Zhao Yingying
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001335
Subject(s) - enol , chemistry , phosphoric acid , scope (computer science) , substrate (aquarium) , combinatorial chemistry , coupling reaction , organic chemistry , catalysis , computer science , oceanography , programming language , geology
We herein report a metal‐free hydrophosphoryloxylation of ynamides with phosphoric acids, which provides an expeditious route to access useful enol phosphates. The advantages of this protocol include exclusive selectivity, short reaction time, high efficiency, and broad substrate scope. Additionally, the products can serve as good partners in Suzuki‐Miyaura cross‐coupling.