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Hydroarylation of N ‐Allenyl Derivatives Catalyzed by Copper **
Author(s) -
Abed Ali Abdine Racha,
Pagès Lucas,
Taillefer Marc,
Monnier Florian
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001333
Subject(s) - chemistry , copper , allylic rearrangement , catalysis , intermolecular force , stereoselectivity , nucleophile , aryl , medicinal chemistry , atom (system on chip) , combinatorial chemistry , organic chemistry , molecule , alkyl , computer science , embedded system
An additive‐free copper catalytic system was used to perform the addition of (hetero)aryl nucleophiles to N ‐allenyl derivatives. This intermolecular C–C bond formation occurs with both complete regio‐ and stereoselectivity to afford the linear ( E ) allylic product with moderate to excellent yields. This atom economical method is the first example of hydroarylation of allenes catalyzed by copper.