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Copper‐Catalyzed Decarboxylative Hydrophosphinylation of α‐Acyl‐α‐Diazoacetates
Author(s) -
Zhang Can,
Dong Chao,
Wang Xin,
Shen Ruwei
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001326
Subject(s) - chemistry , decarboxylation , copper , carbene , catalysis , hydrolysis , organic chemistry , coupling (piping) , reaction conditions , mechanical engineering , engineering
A simple copper‐catalyzed decarboxylation–denitrogenation C–P coupling reaction of α‐acyl‐α‐diazoacetates with hydrophosphoryl compounds is reported. The reaction may proceed via a process involving the generation of (diazomethyl)ketones after hydrolysis in the presence of water and the hydrophosphinylation of the copper carbene intermediates. This finding may suggest the potential use of the relatively more readily available α‐acyl‐α‐diazoacetates as replacement of (diazomethyl)ketones in some cases.