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Cover Feature: Site‐Selective C–H Amidation of 2‐Aryl Quinazolinones Using Nitrene Surrogates (Eur. J. Org. Chem. 46/2020)
Author(s) -
Kim Saegun,
Jeoung Daeun,
Kim Kunyoung,
Lee Seok Beom,
Lee Suk Hun,
Park Min Seo,
Ghosh Prithwish,
Mishra Neeraj Kumar,
Hong Suckchang,
Kim In Su
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001294
Subject(s) - nitrene , chemistry , rhodium , aryl , iridium , catalysis , combinatorial chemistry , borylation , functional group , stereochemistry , organic chemistry , polymer , alkyl
The Cover Feature shows the rhodium(III) and iridium(III)‐catalyzed C–H amidation reaction of 2‐aryl quinazolin‐4(3 H )‐ones with a range of nitrene surrogates including dioxazolones dioxazolones, organic azides, and N ‐methoxyamides through N ‐assisted C–H activation. Complete site‐selectivity and functional group tolerance are observed. Notably, the large‐scale reaction and late‐stage functionalization highlight the synthetic potential of the developed protocol. This work is dedicated to Prof. Pierre H. Dixneuf for his outstanding contribution to organometallic chemistry and catalysis. More information can be found in the Full Paper by S. Hong, I. S. Kim et al.