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Cover Feature: Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization‐Cyclization Process (Eur. J. Org. Chem. 39/2020)
Author(s) -
Di Filippo Mara,
Baumann Marcus
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001282
Subject(s) - quinoline , chemistry , photoisomerization , tandem , enone , combinatorial chemistry , flow chemistry , cover (algebra) , photochemistry , continuous flow , isomerization , organic chemistry , catalysis , materials science , biochemical engineering , mechanical engineering , engineering , composite material
The Cover Feature shows a continuous photochemical process converting amino‐enone substrates into a series of quinoline and tetrahydroquinoline products. The amino‐enone substrates are thereby irradiated with a new high‐power LED lamp in the flow reactor to render the quinoline scaffold in higher efficiency than by using alternative light sources. In a telescoped manner, the quinoline products are then subjected to a Pd‐catalysed hydrogenation process in a reactor that generates hydrogen gas in situ from water. This provides a powerful and green process that delivers various bioactive species including the antimalarial natural product galipinine. More information can be found in the Full Paper by M. Di Filippo and M. Baumann.