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Evolution of Strategies in Protecting‐Group‐Free Synthesis of Natural Products: A Recent Update
Author(s) -
Fernandes Rodney A.,
Kumar Praveen,
Choudhary Priyanka
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001246
Subject(s) - chemistry , protecting group , biochemical engineering , total synthesis , natural (archaeology) , cascade , organic synthesis , group (periodic table) , sustainable development , combinatorial chemistry , organic chemistry , catalysis , engineering , ecology , alkyl , archaeology , chromatography , biology , history
The synthesis of complex natural products must be realized with high economy and efficiency, contributing largely to sustainable development in synthetic organic chemistry. The new strategies should adopt protecting‐group‐free approaches enabling step‐economy and thereby enhancing efficiency. Various approaches based on chiral pool, auxiliary‐based methods, cascade, biomimetic, enzymatic and photocatalytic used in total synthesis of natural products and following the PGF‐criteria over the last two years (2018–2019) have been reviewed here. These should guide sustainable synthesis of natural products in the future.