Au(I)‐Catalyzed Hydration of 1‐Iodoalkynes Leading to α‐Iodoketones | Zendy

GómezHerrera Alberto | Zendy; Hashim Ishfaq Ibni | Zendy; Porré Marre | Zendy; Nahra Fady | Zendy; Cazin Catherine S. J. | Zendy

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Au(I)‐Catalyzed Hydration of 1‐Iodoalkynes Leading to α‐Iodoketones

Author(s) -

GómezHerrera Alberto,

Hashim Ishfaq Ibni,

Porré Marre,

Nahra Fady,

Cazin Catherine S. J.

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202001238

Subject(s) - chemistry , catalysis , halogenation , combinatorial chemistry , organic chemistry , nanotechnology , materials science

A catalytic protocol for the Au(I)‐catalyzed hydration of 1‐iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α‐iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.

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