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Au(I)‐Catalyzed Hydration of 1‐Iodoalkynes Leading to α‐Iodoketones
Author(s) -
GómezHerrera Alberto,
Hashim Ishfaq Ibni,
Porré Marre,
Nahra Fady,
Cazin Catherine S. J.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001238
Subject(s) - chemistry , catalysis , halogenation , combinatorial chemistry , organic chemistry , nanotechnology , materials science
A catalytic protocol for the Au(I)‐catalyzed hydration of 1‐iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α‐iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.