Synthesis of Fluorine‐Containing 3‐Aminocyclopent‐2‐enones via Intramolecular Cyclization | Zendy

Shaitanova Ele. | Zendy; Gerus Igor I. | Zendy; Balabon Olga A. | Zendy; Ivasyshyn Viktor E. | Zendy; Tarasenko Karen V. | Zendy; Daniliuc Constantin G. | Zendy; Haufe Günter | Zendy

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Synthesis of Fluorine‐Containing 3‐Aminocyclopent‐2‐enones via Intramolecular Cyclization

Author(s) -

Shaitanova Ele.,

Gerus Igor I.,

Balabon Olga A.,

Ivasyshyn Viktor E.,

Tarasenko Karen V.,

Daniliuc Constantin G.,

Haufe Günter

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202001218

Subject(s) - chemistry , intramolecular force , fluorine , combinatorial chemistry , organic chemistry

An optimized protocol for the preparation of fluorine‐containing acyclic enones, which are promising building blocks for the preparation of a large variety of fluorinated compounds was developed. These enones easily react with secondary amines to form fluorine‐containing 3‐aminocyclopent‐2‐enones via 4‐amino‐2,3‐dihydrofuran‐2‐ols. The peculiar mechanism involving an intramolecular electrocyclization as a key step is proposed.

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