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Cover Feature: Regulation of Macrocycle Shuttling Rates in [2]Rotaxanes by Amino‐Acid Speed Bumps in Organic–Aqueous Solvent Mixtures (Eur. J. Org. Chem. 36/2020)
Author(s) -
Douarre Maxime,
MartíCentelles Vicente,
Rossy Cybille,
Pianet Isabelle,
McClenaghan Nathan D.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001189
Subject(s) - chemistry , rotaxane , steric effects , aqueous solution , ring (chemistry) , solvent , hydrogen bond , cover (algebra) , molecular machine , molecular dynamics , polymer chemistry , molecule , stereochemistry , computational chemistry , supramolecular chemistry , organic chemistry , nanotechnology , mechanical engineering , materials science , engineering
The Cover Feature shows that movement along a trajectory is regulated in dynamic rotaxane systems even by subtle steric changes imposed by varying incorporated amino acids in the molecular thread component. As elucidated by dynamic and VT NMR studies of a series of two station hydrogen‐bonding molecular shuttles in aqueous and organic solvent, ring movement can be readily tuned by up to four orders of magnitude. Owing to the availability of a wide range of amino acid units, programmed and custom ring shuttling rates in rotaxanes comes one step closer. More information can be found in the Full Paper by N. D. McClenaghan et al.