Premium
Symmetrical Tertiary Amines: Applications and Synthetic Approaches
Author(s) -
Afanasyev Oleg I.,
Kuchuk Ekaterina A.,
Muratov Karim M.,
Denisov Gleb L.,
Chusov Denis
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001171
Subject(s) - chemistry , amination , hydroamination , alkyl , alkylation , tertiary amine , reductive amination , organic chemistry , halide , organic synthesis , combinatorial chemistry , primary (astronomy) , molecule , coupling reaction , cyclic amines , amine gas treating , catalysis , physics , astronomy
Tertiary amines represent a key class of organic molecules with multiple industrial, synthetic, and analytical applications. The focus of this review is on different approaches towards the synthesis of the C 3 and C 3V symmetrical tertiary amines. Generally, symmetrical tertiary amines can be prepared via N‐alkylation with alkyl halides and alcohols, reductive amination, desamination, hydroamination of olefins, and different kinds of C–N cross‐coupling reactions. All reactions leading to the titled structures are discussed, and the advantages and disadvantages of each method are provided.