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Synthesis of 3‐Unsubstituted Phthalides from Aryl Amides and Paraformaldehyde via Ruthenium(II)‐Catalyzed C–H Activation
Author(s) -
Zhou Chao,
Zhao Junqi,
Chen Wenkun,
Imerhasan Mukhtar,
Wang Jun
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001160
Subject(s) - chemistry , phthalide , ruthenium , paraformaldehyde , aryl , intramolecular force , amide , catalysis , carbonylation , tandem , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , materials science , composite material , carbon monoxide
A straightforward and convenient route has been developed for the synthesis of 3‐unsubstituted phthalide derivatives from aryl amides and paraformaldehyde by ruthenium(II)‐catalyzed C–H activation. The reaction proceeds through tandem ortho ‐hydroxymethylation of aryl amide and subsequent intramolecular lactonization.