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The Ugi Three‐Component Reaction; a Valuable Tool in Modern Organic Synthesis
Author(s) -
Tripolitsiotis Nikolaos P.,
Thomaidi Maria,
Neochoritis Constantinos G.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001157
Subject(s) - ugi reaction , chemistry , scope (computer science) , component (thermodynamics) , combinatorial chemistry , drug discovery , focus (optics) , multi component reaction , catalysis , nanotechnology , biochemical engineering , computational chemistry , organic chemistry , isocyanide , computer science , biochemistry , thermodynamics , physics , materials science , optics , programming language , engineering
The Ugi three component reaction (U‐3CR) is a variation of the famous Ugi reaction, discovered almost 60 years ago. Today it is somehow neglected, compared to the classical variation, although the α‐aminoamides, derived from this reaction, have been utilized as inhibitors for various targets and even commercial drugs, offering improved pharmacokinetic properties. In this review, we are describing the scope and limitations of the reaction with a special focus on the developed catalytic protocols, the bioactive compounds, and drugs which are based on the reaction and finally the post modifications that have been reported in order to access drug‐like and privileged scaffolds. A special focus is given to the 3D solid state conformations of the U‐3CR derivatives.